Thanks for all the good news. Glad to see the cyborg option moving forward a little bit. >>34002 Thanks, but next time, please copy some additional information. >New research has now demonstrated it's possible to package and present DNA so it can manage both, providing a full suite of computing functions out of strings of nucleic acids. Specifically, we're talking about storing, reading, erasing, moving, and rewriting data, and handling these functions in programmable and repeatable ways, similar to how a conventional computer would operate. > Researchers from North Carolina State University (NC State) and Johns Hopkins University demonstrated in experiments that their novel nucleic acid scaffold serves as proof of the versatility of DNA computing, and has the potential to build incredibly compact biological machines.

https://turkmenportal.com/en/blog/81956/biocomputer-based-on-brain-cells-now-available-for-rent-for-500-usd >The FinalSpark company presented an innovative service - remote access to a biocomputer operating on human brain cells. This advanced technology is now available to all interested parties for a monthly fee of 500 USD, Ferra.ru reports with reference to Tom's Hardware. >FinalSpark notes that the use of bioprocessors can significantly reduce energy costs when performing complex computing tasks, including training large-scale language models.

>>34105 Finalspark's website https://finalspark.com/biocomputing-the-next-evolutionary-leap/

>>28788 My plan is to integrate biological components like skin into my robowaifu sort of like a t800 terminator once it becomes feasible. Also i cant believe my threads been up for s9 many years

>>34118 Hi DorothyAnon! Good to see you again. :^) >My plan is to integrate biological components like skin into my robowaifu sort of like a t800 terminator once it becomes feasible. I think it's becoming more feasible a possibility by the year. Possibly even by the month! :^) >Also i cant believe my threads been up for s[o] many years Heh, we aim to please. All worthwhile content we strive to keep around. Thanks to Robi's generosity of extending the board's thread's page limit to 25 here, we've managed to pretty much do so. Cheers, Anon. :^) >=== -minor edit

>>34119 If you havent heard im currently in engineering school

>>34127 >If you havent heard im currently in engineering school Woohoo! Grats, Anon. Do you have a major yet? <insert: Sumomo-chan study_real_hard_and_you'll_pass_that_test.jpg.mp4>

>>34129 Not yet. Im doing a transfer degree at my community college first. Ive been working in factories my whole life so probably industrial/controls engineering

>>34118 >sort of like a t800 terminator Cameron is a T-900, btw. https://terminator.fandom.com/wiki/Cameron > mission priority, brother in cover, possible love interest Oniiii-saaan

>>34135 A yandere terminator goth girl would be lit

https://physicsworld.com/a/genetically-engineered-bacteria-solve-computational-problems/ >Now a research team from the Saha Institute of Nuclear Physics in India has used genetically modified bacteria to create a cell-based biocomputer with problem-solving capabilities. The researchers created 14 engineered bacterial cells, each of which functioned as a modular and configurable system. They demonstrated that by mixing and matching appropriate modules, the resulting multicellular system could solve nine yes/no computational decision problems and one optimization problem.

>>34134 Very smart, Anon. >Ive been working in factories my whole life so probably industrial/controls engineering Makes sense. Welp, master PID [1], Anon. Then you should look into Behavioral Trees afterwards, to make everything accessible for use by us mere mortals. Cheers, Anon. :^) Keep.Moving.Forward. --- 1. https://en.wikipedia.org/wiki/Proportional%E2%80%93integral%E2%80%93derivative_controller >>34170 Very intredasting. Thanks, Anon! Cheers. :^)

>>34219 Heres something you should keep an eye on. A human connectome would allow a computer to simulate an entire human brain if it bares fruit. Theyve already done it with a worm and put the simulated brain in robots. A human version would also be theoreti ally possible https://www.humanconnectome.org/

>>34222 >digits There's about a Zeta of synaptic interconnections within the human connectome. AFAICT, we have the most sophisticated -- by far -- neural systems on the planet. So it probably stands to reason that there's much that could be learned by using human neural tissue for such experiments. Thanks for the information, Anon! Cheers. :^)

> keratin based materials as a skin >>34724

https://m.youtube.com/watch?v=3V3CMD_9xXs Wait until the end of the video the dude hooks the slime mold up to a multielectrode array.

>>36946 HAH! Rather-intriguing, Anon. Thanks! Must be fun to play around with cool toys like that lab gear too. Cheers. :^)

The very first commercially available biocomputer has been released by cortical labs for "only" $35,000. Cortical labs is also planning to offer wetware as a service. https://gigazine.net/gsc_news/en/20250305-cortical-labs-cl1/

>>37355 Certainly sounds intriguing, Anon. OTOH, I'm wondering just where they 'sourced' those human brain cells for their culture. Skimming the article, I didn't see mention of that. Thanks for the information, Anon! Cheers. >=== -add'l edit

>>37355 >>37356 At what point does it become a "real" brain that's enslaved? As much I love AI and robotics, I don't want WH40K Servitors.

>>37356 They probably got the neurons off of thermofisher or another supplier. https://www.thermofisher.com/us/en/home/life-science/cell-culture/primary-cell-culture/neuronal-cell-culture.html

>>37362 From what I read; the suppliers got the cells from (hopefully) donors.

>>37363 Most cell cultures are from donors. You would have to find out what cell line the neurons came from to make sure they don't come from an unborn baby or something horrible.

>>37364 OK I pulled up the paper with the pong game also done by Cortical Labs. https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627322008066%3Fshowall%3Dtrue They use human-induced pluripotent stem cells (hiPSCs) https://en.m.wikipedia.org/wiki/Induced_pluripotent_stem_cell These are from adult donors.

>>37366 That's good! Nice research :)

>>37355 If only I had the money

>>37369 If you could find an alternative to the vacuum chamber step you might just be able to build your own. https://pmc.ncbi.nlm.nih.gov/articles/PMC8925300/ >Construction and Implementation of Carbon Fiber Microelectrode Arrays for Chronic and Acute In Vivo Recordings >Multichannel electrode arrays offer insight into the working brain and serve to elucidate neural processes at the single-cell and circuit levels. Development of these tools is crucial for understanding complex behaviors and cognition and for advancing clinical applications. However, it remains a challenge to densely record from cell populations stably and continuously over long time periods. Many popular electrodes, such as tetrodes and silicon arrays, feature large cross-diameters that produce damage upon insertion and elicit chronic reactive tissue responses associated with neuronal death, hindering the recording of stable, continuous neural activity. In addition, most wire bundles exhibit broad spacing between channels, precluding simultaneous recording from a large number of cells clustered in a small area. The carbon fiber microelectrode arrays described in this protocol offer an accessible solution to these concerns. The study provides a detailed method for fabricating carbon fiber microelectrode arrays that can be used for both acute and chronic recordings in vivo. The physical properties of these electrodes make them ideal for stable and continuous long-term recordings at high cell densities, enabling the researcher to make robust, unambiguous recordings from single units across months

>>37379 >Development of these tools is crucial for understanding complex behaviors and cognition and for advancing clinical applications. Heh, good luck with that! As a Substance Dualist, I argue that without the intangible 'spark' of the immaterial parts of the human soul, at best you'll only achieve an animated, zombie-esque, especially-clever automaton -- if human-tier """cognition""" is truly your endgoal. >tl;dr Fat chance, through any naturally-derived means. <---> OTOH, if we can reliably achieve the behavioral characteristics of a gud doggo for our robowaifus, then we will have managed a major breakthrough in bio-psycho-neuro studies! At this point, even achieving something like a good birb's perception/reaction systems would be a yuge.step.forward. <---> In the meantime, we are extremely-likely IMO to be able to achieve highly-satisfying & functional 'mind' simulacrums, for pleasing & effective robowaifus in the nearterm-ish, say 10 year's time (shorter even, if the subject population of consumers is constrained to only autists like myself [& most of Anonymous]). >ttl;dr Robowaifus are inevitable, all else being equal. Its simply a matter of time. >=== -add'l edit

https://www.techradar.com/pro/a-self-destructing-3d-printed-fungi-based-battery-could-one-day-power-sensors-all-around-you-by-feasting-on-sugar >Through a three-year project supported by the Gebert Rüf Stiftung’s Microbials funding program, researchers at Empa (Swiss Federal Laboratories for Materials Science and Technology) have found a novel use for fungi - as they’ve developed a 3D-printed, biodegradable fuel cell that requires feeding rather than charging.

>>37480 That's pretty interesting. Can you give us the >tl;dr for waste management for such devices?

>>37359 > Servitors The thing is: It's just cells, not a full human brain. The real issue would be keeping those alive, cleaning and replacing. I like this thread and it's good we have it, but it's very experimental and fringe. Biology should only be used very sparsely, and only if there are real advantages. >>37492 >waste management for such devices It seems to consume itself and the carrier material, so basically rot away. Which isn't necessarily a problem if it's cellulose based material. Imagine, you want a sensor in nature and reduce the amount of garbage and no need to collect it later. Or consider that most people on the planet are not good at keeping their garbage out of places where it shouldn't go. Now, if they want to power a small device it's better to give them something that doesn't even require a complex recycling procedure. But also, if it's easier to build locally by makers it creates less dependencies, logistic costs and would be cheaper. For all topics here in this thread, in relation to robowaifus, I think the standard solution for waste is to make it flushable and have her pee it out. Of course, if it can be broken down internally to a less repulsive state it's preferable to do so.

>>37535 POTD Highly-insightful take on the waste issues involved, and of this entire topic generally. The idea of using this as some type of thirdie smol power supply is very intriguing IMO. GG, NoidoDev. Cheers. :^)

>>37535 >The thing is: It's just cells, not a full human brain. Then the question is, what counts a human brain. How many neurons does it take? Oddly reminds me of the abortion debate.

>>37540 >How many neurons does it take? Well according to MIT [1], the average brain has ~ 86.1 +/- 8.1 billion neuronal cells (~ x2) within it's constituent tissue. However, the brain of homo sapiens sapiens isn't your standard brain, and the so-called 'connectome' [2] of the human brain is currently estimated at around 1 Zeta [3] of synaptic interconnections. >tl;dr Its not enough just to slop a bunch of tissue together (even if you could manage to keep it all alive); you still have to have a lifetime's worth of human experiences to "program" it properly! :^) --- 1. https://teachmesomething.mit.edu/tms/how-many-neurons-are-there-human-brain/ 2. https://pmc.ncbi.nlm.nih.gov/articles/PMC3555558/ 3. That's 21 zeros, ie; 1'000'000'000'000'000'000'000

>>37549 That's astounding. God designed a supercomputer beyond our wildest fantasies, and make it fit into a bowling ball, and made it run on the power of 4 smartphones

>>37551 Very well-put, Anon, >That's astounding. It truly is. Beyond imagination, really.

>>37549 So basically a robowaifu with an organic brain would be a baby youd have to raise

>>37556 Assuming it was a fully organic brain then yes, but if computers were used to help it train you could accelerate the training time table. Keep in mind biocomputers are brain cells on a microelectrode array. Gene editing might also help speed things up.

>>37556 Roughly-speaking -- all else being equal -- yes. --- However, there's much more to the human soul than simply our brains! While we can simulate this missing sekrit sauce with an amalgam of various techniques for our robowaifus (and btw quite-satisfactorily for the average male or child, I deem), yet we'll never create that 'spark' of humanity that makes us, well, human. No natural means at our disposal can provide that invisible illumination that radiates from all real humans. >tl;dr Its complicated! :^)

Cortical Labs claims to have working computers of silicon + human neurons. https://corticallabs.com/cl1.html Where did these human neurons come from, I'm wondering?

>>38223 https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6? >Here, we aim to establish functional in vitro BNNs from embryonic rodent and human-induced pluripotent stem cells (hiPSCs) on high-density multielectrode arrays (HD-MEAs) to demonstrate that these neural cultures can exhibit biological intelligence—as evidenced by learning in a simulated gameplay environment to alter activity in an otherwise arbitrary manner—in real time >(hiPSCs) https://en.m.wikipedia.org/wiki/Induced_pluripotent_stem_cell >Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. These are from adult donors.

>>38233 Have they solved the telomere issue? I see that iPSCs are claimed to foster telomerase production. From what I gather, any offspring created through these synthesized gametes would still suffer premature aging with lower life expectancy. Exciting progress overall. I can't help but wonder what the true solution to the telomere dilemma will be. Perhaps a customized bacterium which produces proteins needed to alleviate the myriad issues inherent to iPSCs derived clones? I trust your instincts more than my own on this subject so, I want to know your thoughts.

>>38241 Telomerase is not turned off in all of your cells. Telomerase is active in stem cells, T cells, and a couple others in rare cases.

https://www.sciencedirect.com/science/article/abs/pii/S0169433217334554 >Biolithography: Slime mould patterning of polyaniline >Slime mould Physarum polycephalum develops intricate patterns of protoplasmic networks when foraging on a non-nutrient substrates. The networks are optimised for spanning larger spaces with minimum body mass and for quick transfer of nutrients and metabolites inside the slime mould’s body. We hybridise the slime mould’s networks with conductive polymer polyaniline and thus produce micro-patterns of conductive networks. This unconventional lithographic method opens new perspectives in development of living technology devices, biocompatible non-silicon hardware for applications in integrated circuits, bioelectronics, and biosensing.

>>38690 Interesting! I could deffo see that as an effective biosensor mechanism. Thanks, Anon. Cheers. :^)

https://academic.oup.com/synbio/article/10/1/ysaf008/8107742 Engineering a custom-sized DNA scaffold for more efficient DNA origami-based nucleic acid data storage >DNA has emerged as a promising material to address growing data storage demands. We recently demonstrated a structure-based DNA data storage approach where DNA probes are spatially oriented on the surface of DNA origami and decoded using DNA-PAINT. In this approach, larger origami structures could improve the efficiency of reading and writing data. However, larger origami require long single-stranded DNA scaffolds that are not commonly available. Here, we report the engineering of a novel longer DNA scaffold designed to produce a larger rectangle origami needed to expand the origami-based digital nucleic acid memory (dNAM) approach. We confirmed that this scaffold self-assembled into the correct origami platform and correctly positioned DNA data strands using atomic force microscopy and DNA-PAINT super-resolution microscopy. This larger structure enables a 67% increase in the number of data points per origami and will support efforts to efficiently scale up origami-based dNAM. Big names are interested in DNA data storage and they have been for awhile now. https://www.microsoft.com/en-us/research/project/dna-storage/

https://pubs.acs.org/doi/10.1021/acsnano.2c06748?__cf_chl_tk=7ci5gHc50BwdVV9KaVdTFOoLXgO4AEvpP4wZPpisljk-1748748618-1.0.1.1-19YnGYDN96Q7sA.rwAZAVNCc55hpBwlUvt0E7bnnUpo Emerging Approaches to DNA Data Storage: Challenges and Prospects >With the total amount of worldwide data skyrocketing, the global data storage demand is predicted to grow to 1.75 × 1014 GB by 2025. Traditional storage methods have difficulties keeping pace given that current storage media have a maximum density of 103 GB/mm3. As such, data production will far exceed the capacity of currently available storage methods. The costs of maintaining and transferring data, as well as the limited lifespans and significant data losses associated with current technologies also demand advanced solutions for information storage. Nature offers a powerful alternative through the storage of information that defines living organisms in unique orders of four bases (A, T, C, G) located in molecules called deoxyribonucleic acid (DNA). DNA molecules as information carriers have many advantages over traditional storage media. Their high storage density, potentially low maintenance cost, ease of synthesis, and chemical modification make them an ideal alternative for information storage. To this end, rapid progress has been made over the past decade by exploiting user-defined DNA materials to encode information. In this review, we discuss the most recent advances of DNA-based data storage with a major focus on the challenges that remain in this promising field, including the current intrinsic low speed in data writing and reading and the high cost per byte stored. Alternatively, data storage relying on DNA nanostructures (as opposed to DNA sequence) as well as on other combinations of nanomaterials and biomolecules are proposed with promising technological and economic advantages. In summarizing the advances that have been made and underlining the challenges that remain, we provide a roadmap for the ongoing research in this rapidly growing field, which will enable the development of technological solutions to the global demand for superior storage methodologies.

Another paper on DNA origami the field is really interesting. https://www.sciencedirect.com/science/article/pii/S2589004223007150 Self-assembly of DNA origami for nanofabrication, biosensing, drug delivery, and computational storage >Since the pioneering work of immobile DNA Holliday junction by Ned Seeman in the early 1980s, the past few decades have witnessed the development of DNA nanotechnology. In particular, DNA origami has pushed the field of DNA nanotechnology to a new level. It obeys the strict Watson-Crick base pairing principle to create intricate structures with nanoscale accuracy, which greatly enriches the complexity, dimension, and functionality of DNA nanostructures. Benefiting from its high programmability and addressability, DNA origami has emerged as versatile nanomachines for transportation, sensing, and computing. This review will briefly summarize the recent progress of DNA origami, two-dimensional pattern, and three-dimensional assembly based on DNA origami, followed by introduction of its application in nanofabrication, biosensing, drug delivery, and computational storage. The prospects and challenges of assembly and application of DNA origami are also discussed.

This is fascinating stuff, Ribose. Molecular biology is one of my specific interests. And the Information Science crossovers are readily-apparent. Thanks for sharing! Cheers. :^)

https://www.nature.com/articles/s42256-025-01003-z Scalable and robust DNA-based storage via coding theory and deep learning >The global data sphere is expanding exponentially, projected to hit 180 zettabytes by 2025, whereas current technologies are not anticipated to scale at nearly the same rate. DNA-based storage emerges as a crucial solution to this gap, enabling digital information to be archived in DNA molecules. This method enjoys major advantages over magnetic and optical storage solutions such as exceptional information density, enhanced data durability and negligible power consumption to maintain data integrity. To access the data, an information retrieval process is employed, where some of the main bottlenecks are the scalability and accuracy, which have a natural tradeoff between the two. Here we show a modular and holistic approach that combines deep neural networks trained on simulated data, tensor product-based error-correcting codes and a safety margin mechanism into a single coherent pipeline. We demonstrated our solution on 3.1 MB of information using two different sequencing technologies. Our work improves upon the current leading solutions with a 3,200× increase in speed and a 40% improvement in accuracy and offers a code rate of 1.6 bits per base in a high-noise regime. In a broader sense, our work shows a viable path to commercial DNA storage solutions hindered by current information retrieval processes.