>>23359 Oh, haha. My apologies then. :^) I'm rather confident that both the Globohomo and the Chinese are doing just these type experiments r/n. Sauce: my butt

https://www.nature.com/articles/ncomms15261 A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice >Emerging additive manufacturing techniques enable investigation of the effects of pore geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to test how varying pore geometry, accomplished by manipulating the advancing angle between printed layers, affects the survival of ovarian follicles. 30° and 60° scaffolds provide corners that surround follicles on multiple sides while 90° scaffolds have an open porosity that limits follicle–scaffold interaction. As the amount of scaffold interaction increases, follicle spreading is limited and survival increases. Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when implanted in surgically sterilized mice. Moreover, pups are born through natural mating and thrive through maternal lactation. These findings present an in vivo functional ovarian implant designed with 3D printing, and indicate that scaffold pore architecture is a critical variable in additively manufactured scaffold design for functional tissue engineering.

>>23845 I can't read it across Tor. Mind a >tl;dr Ribose?

>>23854 Scientists created embryo like structures using stem cells. This is significant because in the U.S. it is illegal to use embryos older than 14 days for study. So this technology will allow scientists to study human development in later stages without breaking the law.

>>23866 Thanks mate. These wonders of life will never cease to amaze me! :^)

Related: >>23992 (lab egg cells)

https://www.cell.com/cell/fulltext/S0092-8674(23)00807-3 >A human embryo’s legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest “tipping points” for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society. The fact that cell is calling to change the legal definition of embryo is a big deal. These model embryos will help us learn all kinds of things about the development of human life.

>>24726 Personally, I believe embryonic experimenting should be completely legal. Better to live as a lab rat than to be destroyed before teaching certain development thresholds (varies u country). Honestly, I don't understand how destroying the stem cells of a fertilized egg is more ethically correct than letting the child be born with the consequences of the experiments. There's so much to learn, and the person at least has a chance now.

>>24846 > 40yo womb into a 34yo woman

>>24847 >Barren >IVF >Transplanted 40 year old empty egg carton That's a lot of money to cope and seethe over poor life choices. Women really should be warned that being a hoe is only fun for a decade or two then you're forever alone and miserable unless you're an actual 9 or 10. I'm starting to see how urgently we need machine wombs to compensate for undesirable women who lack fore thought and self control. The lord really does give his toughest battles in the strangest ways.

>>24849 >The lord really does give his toughest battles in the strangest ways. Heh, true. :^)

>>24847 I don't get it. Why not using a surrogate? Or working on making such an uterus function outside for the body as long as possible and maintaining itself. This could be done using "donations" from pigs. Related: >>24855 - Sandman and Based Camp

>>25229 Scientists grow whole model of human embryo, without sperm or egg

>The trial would entail a premature infant spending part of its gestation, which should last 40 weeks, in a fluid-filled plastic “bio-bag” that has been designed to mimic the conditions found inside a mother’s uterus. The baby would be supplied with oxygen and nutrients via an artificial placenta attached to its umbilical cord while its lungs remain filled with liquid, as they are in a natural womb. The aim is to improve survival rates, which stand at just 10 per cent for babies born at 22 weeks. >A human trial would involve foetuses on course to be born prematurely – probably between 22 and 24 weeks gestation https://www.theaustralian.com.au/world/the-times/first-human-trial-of-artificial-womb-aims-to-improve-babies-survival-rates/news-story/9cb2aaf79abc2b4a101b3fc004b74356

>>28793 I don't know why you have to make this about IQ and degrading terms, but it will certainly help people to keep their group identity, a level of homogeneity around some neighborhoods or whole countries, and maybe expand their populace instead of dying out. It will quite likely also help some smart or unique people to have children, which otherwise wouldn't have had any, which might have a positive impact.

There's also the issue of malicious involvement in this designer process - as in, how much control you will actually have, and how much trust will you be able to place in whomever will be maintaining the "womb". We already pretty much know for sure that the popular DNA-testing companies tend to, seemingly at random, throw in a couple random result strands just to humble "purer subjects". That's why Europeans are very likely to randomly have subsaharan African DNA show up in their results, and why that one guy who tested his lizard had jewish DNA results come back. In similar vein it's not unlikely that artificial womb companies will secretly make your child mixed, or barely related to you at all, just to stick to their USSR-tier genetic DEI quota. And if you don't like it you're evil and hateful.

>>28802 That's on one hand a legit concern, but the solutions is testing the genes of the baby after birth, and have the technology spread to have enough competition and the looming thread of people doing it on their own. Genetic testing can even be done by biohackers, it was already possible some time ago, I listened to a podcast on it. But I don't know about the details of how many genes can be tested and how well it scales. But feel free to work on making, I think it is called PCR testing, more decentralized. >why Europeans are very likely to randomly have subsaharan African DNA show up in their results I think this is because it's not about the recent ancestors but anyone one down the line. These test are just kinda BS. Only the recent ancestors, the looks (phenotype), and the self-identification with a group based on that, is what matters.

>>28802 >>28810 This whole area is likely to be a domain that's going to be a very difficult one to scale for DIY'rs. OTOH, we here and our frens are are already tackling a ginormous-yuge problemspace, so who knows!? :^)

https://www.technologyreview.com/2024/02/23/1088851/alabama-court-embryo-artificial-wombs/ >It’s common for judges to wrestle with complex questions as they try to apply old laws to new technology. But what’s so unusual about this decision is that the judges ended up giving opinions on technology that hasn’t been fully invented.

This is about as unrealistic as you can get. Artificial wombs might be possible in future but likely not before fetal transplant develops and it won't be something mobile. Even with artificial wombs and if you can start from the beginning of the process you still need eggs and you aren't likely picking those up at the market. At that point you are just essentially doing a surrogate pregnancy with some uknown girl. >>24847 >>24849 >That's a lot of money to cope and seethe over poor life choices. Womb transplants are done for women that lost their womb from surgery because of cancer but want to birth a child or another child. It's very rare because it is a high risk surgery and the womb has to be removed later because it can become necrotic. There has been some successful pregnancies after womb transplants but it really can't be viewed as any way relevant to artificial wombs. >>28810 >Only the recent ancestors, the looks (phenotype), and the self-identification with a group based on that, is what matters. Genotype is what influences phenotype. Phenotype is also influenced by environment. Together this is known as epigenetics. Genotypes can tell you about inheritable illnesses and predispositions to develop something later under right conditions. If you only are speaking of ethnicity or race or more generally ancestry then ethnic groups are more cultural groups built around things like shared language and so on and racial groups are not equivalent to genetic population clusters. Might want to point out babies can have their eye colour and hair colour change to be different from how it looked when they were born, this commonly happens.

https://kr-asia.com/are-synthetic-wombs-the-future-of-childbirth-new-chinese-experiment-sparks-debate >Recently, the First Affiliated Hospital of Zhengzhou University (ZDYFY) announced a groundbreaking synthetic womb experiment without the use of extracorporeal membrane oxygenation (ECMO). In this experiment, a four-month-old fetal lamb survived for 90 minutes while hooked up to a unique apparatus, maintaining vital signs through a connection with its mother.

https://hakaimagazine.com/news/scientists-built-an-artificial-shark-uterus/ >In a new paper published in Frontiers in Fish Science, the researchers show that this manufactured uterus can sustain midterm Moller’s lanternshark embryos for up to a year, about two-thirds of their normal 18-month gestation period. The scientists hope this system will help sharks in their aquarium and eventually be used to bolster wild populations of other endangered shark species.

>>33991 >>34003 Very good news, and I'm also glad they found a reason to justify this research to the general public. Helping with species close to extinction or bringing them back, opens a lot of opportunities to get funding.

Mandela effect: I could've sworn the thumbnail for this thread was a 3D render of a robot woman with transparent stomach/womb

>>38779 I'm probably gonna yeet my own post again, lol soon. I merely checked the date and skimmed it in my busy-ness. I'm having difficulty yet finding any corroborative news on this topic (and can't spend all day at it either). If any'non can help out, great. Otherwise, I don't want to give this f'moid a voice here at all -- especially if this is mere clickbait.

>>38780 Lol. We have that exact image in our vagoo bread OP, maybe? :D

>>38781 The research she was quoting is from the late 90's. Wino here probably just searched up "artificial womb" and yapped about the first results. I looked on Wikipedia, the research is promising. But the question remains: where's the egg coming from? Even cloning technology requires eggs. Perhaps in the far future, with a completely different society, we could have donors give their eggs. Plus, the tech is still in its infancy (no pun intended), so we're decades from having consumer versions, let alone ones that can fit neatly into space the size of an adult female torso. https://en.wikipedia.org/wiki/Artificial_womb >>38782 That was it

>>38781 Colossal biosciences did something similar earlier this year. https://www.iflscience.com/thylacine-de-extinction-achieves-mid-gestation-marsupial-embryo-development-in-artificial-uterus-77640

>>38785 This stuff is advancing a lot faster than I thought it would.

>>38784 >The research she was quoting is from the late 90's. Wino here probably just searched up "artificial womb" and yapped about the first results. Got it. Done. >I looked on Wikipedia, the research is promising. >Perhaps in the far future, with a completely different society, we could have donors give their eggs. Or maybe we'll be able to 'roll our own' soon-ish? * >>38785 Neat! <---> Thanks, Anons. Cheers. :^) --- * As to the gamete haploids, I'm pretty sure both 'sperm' & 'eggs' can be created from stem cells [1]. IIRC male skin cells were used for the results. 1. AFAICT, you only need the genetic 'payloads' (from the cell nucleus) to produce viable embryos. These could be injected into an empty egg cell (and potentially other types as well). https://pmc.ncbi.nlm.nih.gov/articles/PMC4496429/

>>38787 So if both halves come from one side, what's actually going to happen? Would it be just me, just slightly different? Cloning?

>>38789 AFAICT (apart from [presumably] a 50/50 chance of XX vs. XY chromosomes [and all that that implies; to wit: many gene expression variations based on wildly-differing in vivo hormonal conditions, one path or the other])... yes. There will surely be billions & billions of minor phenotypical organelle/cellular variations at birth (growing numerically with time); but in essense -- genetically -- Babby You. And no, not cloning. The DNA's telomere 'clock' is reset properly at conception (which this would be a [admittedly, wildly-different] variant of). Brains are another matter entirely (as are the human souls): they would be unique individuals in most regards (ie, every non- foundationally-biophysical aspect) for that bio-psycho-neural arena. <---> >tl;dr But perhaps our own @Ribose could better answer these questions for us all!? :^)

>>38790 Interesting. So most likely either a copy of me or me with slight differences. It probably wouldn't make a female, because I don't think have two of the same X is viable. It reminds me when feminists were gloating about bone marrow babies (until the lifespan was revealed to be on the order of weeks). One of the points brought up is that the baby would always be female. It seems like a singular-human technological reproduction will always result in the gender of the "parent" >And no, not cloning. The DNA's telomere 'clock' is reset properly at conception I meant cloning in the scientific sense, or as you put it, Babby You. Like Dolly the sheep. This would change society, with effects reaching far beyond gender dynamics. This will be a world where clones (or near clones) are commonplace.

>>38792 >It probably wouldn't make a female, because I don't think have two of the same X is viable. Actually, the process of producing the gamete haploid is a gene-expression process. It will just as likely produce one or the other variation. >One of the points brought up is that the baby would always be female. Because those would be direct, genetic clones. >Like Dolly the sheep. Got it. Yes, not that at all. These people would all be unique offshoots, just like we all are today. >This will be a world where clones (or near clones) are commonplace. So, Gattaca, then? [1] :^). To be quite frank I kinda can't wait!! :D (But we'll need to manage it without maintaining the current, (((kike-world-order))) of things [which the dystopic movie implied].) --- 1. https://www.imdb.com/title/tt0119177/

>>38795 Fascinating. A different, new person from only one person.

>>38797 Exactly. We'd all look much-alike (cf. Identical/Fraternal Twins), but be genetically distinct (just like those twins are). Clones are actually identical, genetically (including telomere-mediated cell lifespan rates [thus the ever-shortening creature lifespans]). But our own Anon's first 'Babby You' lab kit babbys would be distinct newborns...freshly-baked out from the 'Home ArtiWombs' tabletop pods -- complete with a nominally-full lifetime ahead of each of them! :^) What a time to be alive!! :D

>>38800 New question: If I make a robowaifu baby, and GreerTech II makes a robowaifu baby, and so on, will inbreeding effects occur?

>>38801 >will inbreeding effects occur? Yes. Just like it's not a good idea for generation after generation of siblings to breed together (human or otherwise, twins or otherwise), so it wouldn't be good to over-interbreed between the generations (cf. similar: parents, grandparents, etc., effects). A little bit is mostly-OK, genetically (and its how stock breeders fix traits in breeds). Overdoing it will inevitably lead to both diseases & reduced- (or non-) viability for the offspring. Make sense, Anon? <---> >tl;dr I'm sure proper 'genetic markets' will develop over time. And THOTs will be all-too-happy to scrounge for their omega-buxx once pleasing & effective robowaifus hit the scene during the Robowaifu Age to come. Take your pick from the roastie catalog for junior, Anon. I'm sure they'll be eager for the attention! :^)

>>38802 Yes. That means in my scenario, at least a fraction of Greer generations has to get with a human girl to get new genetic material.

>>38804 Yes. Arguably, you should do it at least every other generation, and always drawing from the top stocks available!! <---> Remember, we as a species are degenerating since Adam & Eve (b/c Original Sin, and the effects thereto [ie, no Tree of Life available to us within this universe now, etc.]) You always want the top stocks available for your kids to choose from for the next generation (to help ameliorate the rate of this degeneracy). Exploiting this genetic ill-effect (that you're trying to reduce/avoid here) is the key part of the plot that Satan devised (+ his best little shabbos (((golems))) are currently working hard to $$$carry-out$$$ against us all here in the West) to destroy our many-generations-refined ethnocentric stocks -- so we'd all become a blended, mediocre race of NPC Serfs (& all easily-controlled as well... just like the namesakes). >tl;dr Since during the Robowaifu Age you'll be freed from (((feminist))) influences (at least insofar as actually having one of these """persons""" installed right there in your own home), then you yourself can simply choose the healthiest & prettiest of genes for your kids to reproduce with! And these genetic-stock female's own wretched amorality as 1'000-c*ck-stare THOTs hardly matters once thats all been stripped away to extract fresh new gametes (only) * from her for your kid's kids to mix with. :^) --- * That is, don't use her decrepit eggs directly! Generate brand-new gametes from her purified stemcells instead (inside your own safe & clean lab facility).

>>38784 >where's the egg coming from? This is not a problem. Eggs of mice have been made from skin cells. I assume blood cells would work. http://www.nextbigfuture.com/2017/05/mice-embryos-from-skin-cells-and-by-2037-human-embryos-from-skin-cells.html I suspect any Women would sell a scraping of cells for $1,000, likely way less. Women believe they are the keepers of life but facts are that it is sperm that is needed to start the dividing and transformation of egg cells. Women are not needed. https://www.theverge.com/2017/4/25/15421734/artificial-womb-fetus-biobag-uterus-lamb-sheep-birth-premie-preterm-infant Artificial wombs are, best as I know, in infancy but I bet with a god deal of research, and cash, it could be done. I did some basic rough math guesses for researchers, equipment, etc. to build a artificial womb and I came up with a sum of $2,820,000 a year for a well appointed task force to build these. Most breakthroughs for some reason, I don’t know why, generally take 30 years to become mainstream. So total cost set-up running and all for 30 years is $93,550,000. People who pay this kind of money for yachts and vacation homes can easily afford this and I think my cost are a bit lavish. You could do this much cheaper for most of the research. This is a stand up and do it now type budget. A real problem is ethical. To do this fast you are going to have to destry a LOT of non viable specimens, or people. I would not be in the least surprised if the Deep State has not already done this and used the offspring for vile nefarious purposes.

>>38857 POTD Very-intredasting ideas, Grommet. Cheers. :^)

>>38857 >to do this fast you are going to have to destry a LOT of non viable specimens, or people. I would not be in the least surprised if the Deep State has not already done this and used the offspring for vile nefarious purposes. Given the amount of different countries working on artificial wombs (China and the US being the leaders) this is a safe bet.

Chinese researchers have produced (apparently viable, though short-lived) mouse offspring from male-only parent(s); via gene-editing of embryonic pluripotent stem cells. >paper: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00005-0 >leader: http://english.ioz.cas.cn/sourcedb/scs/202310/t20231030_431101.html

Not directly related to artificial wombs, but decellularized and recellularized mycelium are being investigated for lab grown meat and tissue scaffolds. I wonder if something like this could be recellularized using cells from the lining of the womb. https://pmc.ncbi.nlm.nih.gov/articles/PMC8209158/ >Advanced mycelium materials as potential self-growing biomedical scaffolds https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.2c00093 >In vitro Insect Fat Cultivation for Cellular Agriculture Applications https://pubs.rsc.org/en/content/articlelanding/2020/tb/d0tb01751e >Bioreactivity of decellularized animal, plant, and fungal scaffolds: perspectives for medical applications https://www.sciencedirect.com/science/article/abs/pii/S0308814625020783 >Evaluation of various mushroom-based scaffolds for application to cellular agriculture Similar things have been done with various plants as well. https://www.nature.com/articles/s41538-024-00262-1 >Decellularised plant scaffolds facilitate porcine skeletal muscle tissue engineering for cultivated meat biomanufacturing